Micro and Nano Technologies for Point-of-Care Testing
Introduction
Micro and nanotechnologies are set to transform point-of-care diagnostics. Miniaturization of testing methods, advances in lab-on-a-chip microfluidic methodologies, improvements in detection technologies and novel biosensors are leading the way.
Features and benefits
Various proprietary technologies identified in this report underpin POC testing products in development. These technologies represent valid alternative approaches to challenges such as multiplexing, liquid transport in miniaturized systems, integration of assay procedures, and limitations associated with the use of traditional fluorescent labels.
The microfluidic lab-on-a-chip (LoC) is now firmly established as an attractive miniaturized platform for POC testing. Maturing of LoC technologies is stimulating efforts to incorporate miniaturized biosensors into portable LoC systems to accelerate the development of portable and handheld testing systems
Most of the products discussed in this report are being developed for healthcare professional-based testing. Four professional-based POCT market sectors - infectious disease; cardiac marker; coagulation (including pharmacogenomics); and cancer screening/pharmacogenomics - are forecast to grow at CAGRs of 14%, 22%, 19% and 30% respectively.
Your key questions answered
Micro and nanotechnologies are set to transform point-of-care diagnostics. Miniaturization of testing methods, advances in lab-on-a-chip microfluidic methodologies, improvements in detection technologies and novel biosensors are leading the way.
Features and benefits
- Identify micro and nanotechnologies driving the development of next-generation point-of-care diagnostics to benefit from opportunities being created.
- Discover which analytes/diseases are currently being targeted by profiled companies to formulate your own diagnostic product development strategies.
- Assess the evolving POC testing market with the aid of market forecasts for individual market segments to prepare for future growth in this area.
- Forecast key point-of-care testing market segments to 2016.
Various proprietary technologies identified in this report underpin POC testing products in development. These technologies represent valid alternative approaches to challenges such as multiplexing, liquid transport in miniaturized systems, integration of assay procedures, and limitations associated with the use of traditional fluorescent labels.
The microfluidic lab-on-a-chip (LoC) is now firmly established as an attractive miniaturized platform for POC testing. Maturing of LoC technologies is stimulating efforts to incorporate miniaturized biosensors into portable LoC systems to accelerate the development of portable and handheld testing systems
Most of the products discussed in this report are being developed for healthcare professional-based testing. Four professional-based POCT market sectors - infectious disease; cardiac marker; coagulation (including pharmacogenomics); and cancer screening/pharmacogenomics - are forecast to grow at CAGRs of 14%, 22%, 19% and 30% respectively.
Your key questions answered
- Which micro and nano technologies in development offer the attributes of miniat
- What drivers and restraints operate in the nascent market for POC testing products based on micro and nanotechnologies?
- Who is developing new POC testing products based on micro and nanotechnologies and which clinical applications are they targeting?
- How will POC testing products based on micro and nanotechnologies impact areas inadequately served by current products and areas of unmet need?
- What are the estimated current market sizes and 5-year growth forecasts for the sectors of the POC testing market currently targeted?
EXECUTIVE SUMMARY
Key findings
The effects of evolving diagnostic technologies
CURRENT POCT TECHNOLOGIES AND APPLICATIONS
Summary
Introduction
Enabling IVDT technologies
Immunoassays
Probe-based nucleic acid testing
Mass spectrometry
Regulation of IVDs
Current POCT systems
Multi-channel immunoanalyzers
Micro- and nanotechnologies for POCT
MICRO- AND NANOARRAYS
Summary
Introduction
Developments in DNA microarrays
High density microarrays
Low or medium density microarrays
Microarray platforms
Developments in protein microarrays
Focus on detection technologies
Label-based technologies
Label-free technologies
Innovations in nanoarrays
Nanofabrication techniques
Applications
MICROFLUIDICS ‐ BASED LOC SYSTEMS
Summary
Mirofluidic devices and technologies
Microfluidic NAT systems
Integrated LoC commercial systems
Microfluidic immunoassays
Substrate materials for microfluidic immunoassays
Immobilization methods for immunoassays
Liquid transport control strategies
Micropneumatic pumping
Multilayer soft lithography
Centrifugal force
Phaseguide technology
Electrokinetics
Electrowetting
Other approaches
Detection methods
Optical detection using labels
Non-optical label-free technologies
ADVANCES IN BIOSENSORS
Summary
Introduction
Advances in optical detection
Signal intensification technologies
Optical fiber technology
Electrochemical sensors
Piezoelectric sensors
Nanomaterial-based biosensors
Challenge of non-specific protein adsorption
Nanoparticles for sensor devices
Quantum dots and gold nanoparticles
Magnetic nanoparticles
Nanoelectrodes
Nanotubes
Nanowires
Nanopore sensors
Biological nanopores
Solid-state and hybrid nanopores
Artificial olfaction sensors
Other sensors
COMPANY PROFILES
Introduction
Advanced Liquid Logic
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Recent POCT-related collaborations
Akonni Biosystems
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Recent POCT-related collaborations
Applied Nanodetectors
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Aquila Diagnostic Systems
Overview of company business
Proprietary micro/nanotechnologies
POCT products
ArcDia International
Overview of company business
Proprietary micro/nanotechnologies
POCT products
BioCartis
Overview of company business
Proprietary micro/nanotechnologies
Recent POCT-related collaborations
BioForce Nanosciences
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Bio-Rad Laboratories
Company description
Proprietary micro/nanotechnologies (acquired from QuantaLife)
POCT products
Biosurfit
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Biosystems International
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Recent POCT-related collaborations
Cambridge Biomagnetics
Overview of company business
Proprietary micro/nanotechnologies
POCT products
DNA Electronics
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Recent POCT-related collaborations
Epocal
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Recent POCT-related collaborations
Fluidigm
Overview of company business
Proprietary micro/nanotechnologies
FluimediX
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Fluigent
Overview of company business
Proprietary micro/nanotechnologies
GenMark Diagnostics
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Integrated Nano-Technologies
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Kumetrix
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Luminex Corporation
Overview of company business
Proprietary micro/nanotechnologies
POCT products
MagArray
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Micronics
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Molecular Vision
Overview of company business
Proprietary micro/nanotechnologies
POCT products
NanoIVD
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Nanomix
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Nanosphere
Overview of company business
Proprietary micro/nanotechnologies
POCT products
NVE Corporation
Overview of company business
Proprietary micro/nanotechnologies
POCT products
OJ-Bio
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Oxford Nanopore Technologies
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Recent POCT-related collaborations
PLC Diagnostics
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Royal Philips Electronics
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Recent POCT-related collaborations
PLC Diagnostics
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Sirigen
Overview of company business
Proprietary micro/nanotechnologies
POCT products
T2 Biosystems
Overview of company business
Proprietary micro/nanotechnologies
POCT products
TIRF Technologies
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Vivacta
Overview of company business
Proprietary micro/nanotechnologies
POCT products
MARKET TRENDS AND FORECASTS
Summary
Technologies poised t-transform POCT
The future: early treatment and prevention
Characteristics of the IVD industry
Challenges for developers of novel POCT products
POCT market forecasts by selected application
Infectious disease testing
Cardiac marker testing
Coagulation testing and pharmacogenomics
Cancer screening and pharmacogenomics
APPENDIX
Contributors
Managing analyst
Scope
Methodology
Glossary/abbreviations
Bibliography/references
Websites of companies mentioned in this report
Disclaimer
Key findings
The effects of evolving diagnostic technologies
CURRENT POCT TECHNOLOGIES AND APPLICATIONS
Summary
Introduction
Enabling IVDT technologies
Immunoassays
Probe-based nucleic acid testing
Mass spectrometry
Regulation of IVDs
Current POCT systems
Multi-channel immunoanalyzers
Micro- and nanotechnologies for POCT
MICRO- AND NANOARRAYS
Summary
Introduction
Developments in DNA microarrays
High density microarrays
Low or medium density microarrays
Microarray platforms
Developments in protein microarrays
Focus on detection technologies
Label-based technologies
Label-free technologies
Innovations in nanoarrays
Nanofabrication techniques
Applications
MICROFLUIDICS ‐ BASED LOC SYSTEMS
Summary
Mirofluidic devices and technologies
Microfluidic NAT systems
Integrated LoC commercial systems
Microfluidic immunoassays
Substrate materials for microfluidic immunoassays
Immobilization methods for immunoassays
Liquid transport control strategies
Micropneumatic pumping
Multilayer soft lithography
Centrifugal force
Phaseguide technology
Electrokinetics
Electrowetting
Other approaches
Detection methods
Optical detection using labels
Non-optical label-free technologies
ADVANCES IN BIOSENSORS
Summary
Introduction
Advances in optical detection
Signal intensification technologies
Optical fiber technology
Electrochemical sensors
Piezoelectric sensors
Nanomaterial-based biosensors
Challenge of non-specific protein adsorption
Nanoparticles for sensor devices
Quantum dots and gold nanoparticles
Magnetic nanoparticles
Nanoelectrodes
Nanotubes
Nanowires
Nanopore sensors
Biological nanopores
Solid-state and hybrid nanopores
Artificial olfaction sensors
Other sensors
COMPANY PROFILES
Introduction
Advanced Liquid Logic
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Recent POCT-related collaborations
Akonni Biosystems
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Recent POCT-related collaborations
Applied Nanodetectors
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Aquila Diagnostic Systems
Overview of company business
Proprietary micro/nanotechnologies
POCT products
ArcDia International
Overview of company business
Proprietary micro/nanotechnologies
POCT products
BioCartis
Overview of company business
Proprietary micro/nanotechnologies
Recent POCT-related collaborations
BioForce Nanosciences
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Bio-Rad Laboratories
Company description
Proprietary micro/nanotechnologies (acquired from QuantaLife)
POCT products
Biosurfit
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Biosystems International
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Recent POCT-related collaborations
Cambridge Biomagnetics
Overview of company business
Proprietary micro/nanotechnologies
POCT products
DNA Electronics
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Recent POCT-related collaborations
Epocal
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Recent POCT-related collaborations
Fluidigm
Overview of company business
Proprietary micro/nanotechnologies
FluimediX
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Fluigent
Overview of company business
Proprietary micro/nanotechnologies
GenMark Diagnostics
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Integrated Nano-Technologies
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Kumetrix
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Luminex Corporation
Overview of company business
Proprietary micro/nanotechnologies
POCT products
MagArray
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Micronics
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Molecular Vision
Overview of company business
Proprietary micro/nanotechnologies
POCT products
NanoIVD
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Nanomix
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Nanosphere
Overview of company business
Proprietary micro/nanotechnologies
POCT products
NVE Corporation
Overview of company business
Proprietary micro/nanotechnologies
POCT products
OJ-Bio
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Oxford Nanopore Technologies
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Recent POCT-related collaborations
PLC Diagnostics
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Royal Philips Electronics
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Recent POCT-related collaborations
PLC Diagnostics
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Sirigen
Overview of company business
Proprietary micro/nanotechnologies
POCT products
T2 Biosystems
Overview of company business
Proprietary micro/nanotechnologies
POCT products
TIRF Technologies
Overview of company business
Proprietary micro/nanotechnologies
POCT products
Vivacta
Overview of company business
Proprietary micro/nanotechnologies
POCT products
MARKET TRENDS AND FORECASTS
Summary
Technologies poised t-transform POCT
The future: early treatment and prevention
Characteristics of the IVD industry
Challenges for developers of novel POCT products
POCT market forecasts by selected application
Infectious disease testing
Cardiac marker testing
Coagulation testing and pharmacogenomics
Cancer screening and pharmacogenomics
APPENDIX
Contributors
Managing analyst
Scope
Methodology
Glossary/abbreviations
Bibliography/references
Websites of companies mentioned in this report
Disclaimer
TABLES
Table: Selected companies developing microfluidic POC lab-on-a-chip systems
Table: Selected companies developing biosensors for POCT applications
Table: Global POCT market forecasts by reviewed segment, 2011–16
Table: Selected companies developing microfluidic POC lab-on-a-chip systems
Table: Selected companies developing biosensors for POCT applications
Table: Global POCT market forecasts by reviewed segment, 2011–16
FIGURES
Figure: Schematic of a typical lateral flow device
Figure: Customizable features of the ESE-Quant lateral flow system
Figure: Akonni Systems’ TruArray gel microarray
Figure: PLC Diagnostics’ In-plane parallel scanning
Figure: A typical lab-on-a-chip for POC testing with associated instrumentation
Figure: PCR analysis on Advanced Liquid Logic’s electrowetting chip
Figure: Schematic of a lab-on-a-chip for fluorescence analysis
Figure: Molecular Vision's polymer detection system and credit card-sized LoC device
Figure: GenMark Diagnostics’ eSensor technology
Figure: NVE Corporation’s spintronic sensor
Figure: Schematic of a Surface Generated Acoustic Wave (SGAW) sensor
Figure: Schematic of a typical lateral flow device
Figure: Customizable features of the ESE-Quant lateral flow system
Figure: Akonni Systems’ TruArray gel microarray
Figure: PLC Diagnostics’ In-plane parallel scanning
Figure: A typical lab-on-a-chip for POC testing with associated instrumentation
Figure: PCR analysis on Advanced Liquid Logic’s electrowetting chip
Figure: Schematic of a lab-on-a-chip for fluorescence analysis
Figure: Molecular Vision's polymer detection system and credit card-sized LoC device
Figure: GenMark Diagnostics’ eSensor technology
Figure: NVE Corporation’s spintronic sensor
Figure: Schematic of a Surface Generated Acoustic Wave (SGAW) sensor
