Spinal Orthopaedics: A bright future for new technologies?

Date: September 22, 2008
Pages: 242
Price:
US$ 2,265.00
Publisher: Espicom Business Intelligence
Report type: Strategic Report
Delivery: E-mail Delivery (PDF)
ID: S64E1461042EN
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Spinal Orthopaedics: A bright future for new technologies?
“By 2012, the global spinal market will achieve revenues of US$10.2 billion and a CAGR of 12% - with faster growth in the future expected”

Although motion preservation devices are expected to take some share from fusion products, this will be offset in the near-term by the rising number of people with spine-related disorders for whom fusion remains the most viable treatment and the increasing adoption of MIS-friendly fusion techniques.

Total Disc Replacement...

The use of current lumbar TDRs is not expected to have a significant impact on the fusion market until products that use the posterior approach are developed, although clinical evidence that promotes current products may lead to a slight improvement in this market. Espicom believes cervical TDRs represent a significant market opportunity and should experience strong growth once they receive reimbursement approval in the US, which is not expected to occur until 2009 at the earliest.

...Nucleus Replacement & Dynamic Stabilisation

The potential for nucleus replacement products is currently questionable and Espicom does not believe these products will have a major impact on the market in the near to mid-term. However, dynamic stabilisation products have already proved their worth in Europe and are expected to drive growth in the spinal surgery market in coming years, with an acceleration expected from 2012 as more of these products become available in the US and Japan.

This report provides real insights…

For executives working in industry and commerce, the need to understand the issues, players and products in this sector of high-growth potential is essential. That is why Espicom, for 27 years a leading publisher of strategic business information for the medical device community, has published this extensive new report.

In over 240-pages, the report examines the background to market, provides key figures and estimates for market growth and examines in-depth the companies and innovative products that are driving change.

This report answers key business questions…
  • What factors will drive the nucleus replacement market to revenues of $450 million in 2012?
  • What impact will the increasing use of minimally- invasive surgical techniques have on the disc fusion sector?
  • What % of the global market will dynamic stabilisation systems command in 2012?
  • What is the potential for minimally-invasive spinal technology?
  • How might Synthes and DePuy challenge Medtronic’s domination of the spinal sector?
  • Which emerging US company successfully launched a lumbar TDR product in Europe in May 2008?
  • Why is industry interest in vertebral compression fractures increasing?
EXECUTIVE SUMMARY

OVERVIEW

THE SPINAL SURGERY MARKET

Global Spinal Market by Procedure, 2006-2007 (US$ million)
Fig.1: Global Spinal Market by Procedure, 2007
Global Spinal Market by Region, 2006-2007 (US$ million)
Fig.2: Global Spinal Market by Region, 2007
United States
US Clinical Procedures by CCS Code 158 (Spinal Fusion), 1996-2006
Europe
Asia-Pacific Region

MARKET PLAYERS

Fig.3: Global Spinal Market Shares, 2007*
Fig.4: Global Spinal Market Shares, 2006*
Manufacturers’ Spinal Sales, 2003-2008 (US$ million)*
Companies Ranked by Spinal Sales Growth, 2006-2007 (US$ million)

MARKET DYNAMICS

Gaining Clinical Evidence
SPORT Study
Intervertebral Disc Herniation
Degenerative Spondylolisthesis
Spinal Stenosis
Increasing Competition
The Role of Private Equity
Major Private Equity Companies’ Spinal Portfolios
Industry Consolidation
Major Spinal Acquisitions, 2006-2008

FUTURE TRENDS AND FORECASTS

Fig.5: Global Spinal Market, 2006-2015 (US$ million)
Global Spinal Market by Procedure Type, 2007-2013 (US$ million)
Fig.6: Global Spinal Market, 2006-2015 (US$ million)
Fig.7: Global Spinal Market by Procedure, 2013

SPINAL PRODUCTS AND TECHNOLOGIES

SPINAL FUSION

The Fusion Market
Fig.8: Global Spinal Fusion Market, 2006-2013 (US$ million)
Fusion: Market Drivers, Restraints & Future Opportunities
Thoracolumbar Products
Product Highlights
Abbott’s Universal Clamp
Alphatec’s Zodiac Line
Amedica’s Valeo Pedicle Screw System
Custom Spine’s ISSYS Products
DePuy’s Expedium Products
Globus Medical’s Reverse and Gateway Systems
Life Spine’s Lynx Cross Connector System
MEDICREA’s PASS Products
Medtronic Products
Pioneer Surgical Technology’s LowTop Pedicle Screw System
SIGNUS Medizintechnik’s TPN
Stryker’s Xia Spinal System
Surgicraft’s Products
Synthes’ Pangea Degenerative Spine System
US Spine’s Facet Fixation System
X-spine Systems’ Capless Pedicle Screw Systems
New Anterior Lumbar Plates
Interbody Devices
Product Highlights
Alphatec’s Novel Spinal Spacer Systems
Amedica’s Valeo and Arx System
Globus Medical’s NIKO Corpectomy Spacer System
K2M’s Aleutian Systems
LDR Holdings’ ROI Partial VBRs
Medtronic’s Capstone
RSB Spine’s InterPlate VBRs
Spinal Elements’ VBRs
Stryker’s AVS PL PEEK Spacers
Synthes’ Products
Vertebration’s XYcor Spinal Implant
Cervical Products
New Anterior Cervical Plate Systems
Spinal Elements’ Mosaic Spinal Implant System

MEDICREA’s C-JAWS

Minimally-Invasive Spinal Fusion
MIS Fusion: Market Drivers, Restraints & Future Opportunities
Leading Products and New Innovations
Abbott’s Minimally-Invasive Systems
Alphatec’s Illico Minimally Invasive System
Biomet’s VuePASS Portal Access Surgical System
coLigne’s Erriva ELIF
DePuy’s MIS Products
Globus Medical’s MARS Minimal Access Retractor System
Innovative Spinal Technologies’ Paramount Systems
Interventional Spine’s MIS Products
K2M’s Serengeti Minimally Invasive Retractor System
Medtronic Minimal Access Spinal Technologies
NuVasive Maximum Access Surgery
Pioneer Surgical Technology’s Quantum MIS Rodding System
Spinal Elements’ Mercury Spinal System
Stryker’s MANTIS
TranS1’s MIS Approach
VertiFlex’ Silverbolt MIS Systems
Zimmer’s Endius Products

BIOLOGIC PRODUCTS

Orthobiologics Market by Product, 2007-2012 (US$ million)
Orthobiologics Market by Region 2007-2012
Fig.9: Global Orthobiologics Market Shares, 2007
Bone Graft Substitutes
Spinal Biologics: Market Drivers, Restraints & Future Opportunities
Allograft
Demineralised Bone Matrix
Bone Morphogenetic Proteins
Medtronic’s Infuse Bone Graft
Medtronic’s InductOs
Stryker’s OP-1
Synthetic Bone Grafts
New Synthetic Bone Grafts
Cell-Based Products
NuVasive’s Osteocel
SpineSmith’s Fusionary
Technologies in Development
Orthovita’s Cortoss Bone Augmentation Material
Other Biologic Spinal Products
co.don’s chondrotransplant DISC
ISTO Technologies’ NuQu Injectable Cell-Based Therapy
Spinal Restoration’s Biostat Disc Augmentation System
SpineOvations’ DiscSeal
Integra LifeSciences’ DuraGen Plus Adhesion Barrier Matrix

DYNAMIC STABILISATION

Fig.10: Dynamic Stabilisation Market, 2006-2013 (US$ million)
Dynamic Stabilisation: Market Drivers, Restraints & Future Opportunities
Pedicle Screw-Based Systems
Pedicle Screw-Based Systems - Competitive Landscape
Zimmer’s Dynesys Dynamic Stabilization System
Zimmer DTO Implant
Scient’x’ Isobar Products
Paradigm Spine’s coflex Devices
Paradigm Spine’s DSS System
SpineVision’s FlexPLUS
Disc Motion Technologies’ True TSMS
Interventional Spine’s PercuDyn
Applied Spine Technologies’ Stabilimax NZ
Vertiflex’ Dynabolt Dynamic Stabilization System
Eden Spine’s FX-1 System
ulrich Medical’s cosmic Products
Products in Development
DePuy’s Expendium Dynamic Rod System
Globus Medical’s Transition Posterior Dynamic Stabilization System
Innovative Spinal Technologies’ Axient Total Dynamic Fixation
Interspinous Spacer Systems
Interspinous Spacers - Competitive Landscape
Medtronic/Kyphon’s X-STOP Interspinous Process Decompression System
Abbott’s Wallis System
Medtronic’s DIAM Spinal Stabilization System
Medtronic/Kyphon’s Aperius PercLID
VertiFlex’ Superion
Synthes’ In-Space
Orthofix’ InSWing
Globus Medical’s FLEXUS Interspinous Spacer
Pioneer Surgical Technology’s BacJac
Eden Spine’s Wellex Interspinous Technology
GMReis’ Dynafix Interspinous Dynamic Fixation System

TOTAL DISC REPLACEMENT

Fig.11: Global TDR Market, 2006-2013 (US$ million)
Lumbar Discs
Market Potential and Future Opportunities
Fig.12: Lumbar TDR Market, 2006-2013 (US$ million)
Lumbar TDR: Market Drivers, Restraints & Future Opportunities
Lumbar TDR Products and Technologies
Lumbar TDR: Competitive Landscape
DePuy’s Charité Artificial Disc
Synthes’ ProDisc-L
Medtronic’s Maverick Artificial Lumbar Disc
Nexgen Spine’s Physio-L
Stryker’s FlexiCore Artificial Lumbar Disc
SpinalMotion’s Kineflex
Aesculap’s Activ-L Artificial Lumbar Disc
Disc Motion Technologies’ TrueDisc Posterior Artificial Disc
LDR Holdings’ Mobidisc
Zimmer’s Dynardi Artificial Lumbar Disc
Products in Development
Cervical Discs
Fig.13: Cervical TDR Market, 2006-2013 (US$ million)
Cervical TDR: Market Drivers, Restraints & Future Opportunities
Cervical TDR Products and Technologies
Cervical TDRs - Competitive Landscape
Synthes’ ProDisc-C
Medtronic’s Prestige Cervical Disc
Medtronic’s Prestige LP Cervical Disc
Medtronic’s Bryan Cervical Disc System
Scient'x’ Discocerv
Cervitech’s PCM Artificial Cervical Disc
LDR’s Mobi-C
Globus Medical’s Secure-C
SpinalMotion’s Kineflex|C
DePuy’s Discover Cervical Disc
Spinal Kinetics’ M6-C
Vertebron’s CMP
Osteon’s MCD Mobile Cervical Disc
Aesculap’s Activ-C
Products in Development

PARTIAL DISC REPLACEMENT

Nucleus Replacement
Fig.14: Nucleus Replacement Market, 2006-2013 (US$ million)
Nucleus Replacement: Market Drivers, Restraints and Future Opportunities
Nucleus Replacement Products and Technologies
Nucleus Replacement - Competitive Landscape
Raymedica’s Products
Disc Dynamics’ Dascor Disc Arthroplasty System
Pioneer Surgical Technology’s NuBac Intradiscal Arthroplasty System
Sinitec’s SINUX ANR
Products in Development
NuVasive’s NeoDisc Cervical Partial Disc Replacement
TranS1’s PDR Lumbar Partial Disc Replacement

NUCLEUS REMOVAL

FACET REPLACEMENT

Archus Orthopedics’ Total Facet Arthroplasty Systems
Facet Solutions’ Anatomic Facet Replacement System
Spinal Elements’ Zyre Facet Arthroplasty System
Gerraspine’s FENIX Facet Implant

TOTAL POSTERIOR ARTHROPLASTY

TOPS-on-Fusion System

ANNULAR REPAIR

Anulex Technologies’ Inclose and Xclose Systems
Intrinsic Therapeutics’ Barricaid
Arthro Kinetics’ AnReS

FRACTURE TREATMENT

Current Options
VCF Treatment Options: Vertebroplasty vs Kyphoplasty
Market Players
Fig.15: VCF Treatment Market, 2006-2013 (US$ million)
Vertebroplasty
ArthroCare - Parallax Medical and Cavity SpineWand
Kyphoplasty and Kyphon
Fig.16: Kyphon: Kyphoplasty Procedure Growth, 2000-2006
Fig.17: Kyphon’s Revenue, Y/E 31st December 2000-2006 (US$ million)
Kyphon’s SKy Bone Expander System
Spine Wave’s StaXx FX Structural Kyphoplasty System
Cement & Cement Delivery Systems
DePuy’s Confidence Spinal Cement System
Biomet’s VCF Products
Orthovita’s Cortoss Bone Augmentation Material
Spineology’s OptiMesh
Products in Development
Alphatec’s OsseoFix Spinal Fracture Reduction System
AOI Medical’s Ascendx VCF Reduction System

SPINAL IMPLANT MANUFACTURERS

THE MARKET LEADERS

Abbott
Abbott: Recent Spinal Product Approvals
Alliances
Replication Medical
AlloSource
Invibio
Financial Performance
Abbott Revenue, 2004-2007 (US$ million)
Fig.18: Abbott Spine Sales, 2004-2007 (US$ million)*
Alphatec Holdings
Alphatec: Recent Product Approvals
R&D Projects
Alliances
DePuy
Scient'x
Stout Medical Group
Progressive Spinal Technologies
JGMG Bengochea
Roger P Jackson, MD
Biomet
Hansen A Yuan
Invibio
Financial Performance
Alphatec Revenue, 2004-2007 (US$ million)
B Braun/Aesculap
Alliances
Premier
Inion
Integra OrthoBiologics
Allez Spine
Financial Performance
B Braun Revenue, 2004-2007 (US$ million)
Biomet
Alliances
Premier
Alphatec Holdings
Altiva
Financial Performance
Biomet Revenue, 2005-2008 (US$ million)
Fig.19: Biomet: Spinal Revenue, 1998-2008 (US$ million)
DePuy
DePuy: Recent Spinal Product Launches
R&D Projects
Alliances
Alphatec Holdings
Biomerix
Axial Biotech
Archus Orthopedics
Sinitec
Osteotech and LifeNet
FzioMed
Harvest Technologies
DJO
Biedermann Motech GmbH
Legal Proceedings
Financial Performance
DePuy Revenue, 2004-2007 (US$ million)
Globus Medical
Fig.20: Globus Medical’s Revenue, 2003-2008 (US$ million)
Globus: Recent Product Approvals
R&D Projects
Medtronic
Medtronic: Recent Spinal Product Approvals
R&D Projects
Alliances
Chinese Spine and Orthopaedics Joint Venture
Orthofix International (Blackstone Medical)
Kensey Nash
aap Implantate
RTI Biologics
Premier
Wyeth, Integra OrthoBiologics and Astellas
Axial Biotech
Purdue Research Foundation
Kyphon Agreements
Financial Performance
Fig.21: Medtronic’s Spinal Sales by Product Area, 2008
Fig.22: Medtronic’s Spinal Sales by Region, 2008
Medtronic’s Spinal Revenue, 2007-2008 (US$ million)
Fig.23: Kyphon’s Revenue, Y/E 31st December 2000-2006 (US$ million)
NuVasive
NuVasive: Recent Product Launches
R&D Projects
Alliances
Orthofix/Blackstone Medical
Theken Spine
Maxigen Biotech
Tissue Banks International and AlloSource
Pearsalls
Invibio
Peak Industries
Financial Performance
Fig.24: NuVasive’s Revenue, 2003-2007 (US$ million)
Orthofix International
R&D Projects
Alliances
Musculoskeletal Transplant Foundation
RTI Biologics
UnitedHealth
NuVasive
Innovative Spinal Technologies
Legal Proceedings
Financial Performance
Orthofix Revenue By Product, 2004-2007 (US$ million)
Orthofix Spine Sales by Segment, 2004-2007 (US$ million)
Stryker
Stryker: Recent Spinal Product Launches
R&D Projects
Next-generation Spinal Implants
New Indications for OP-1
Alliances
LifeCell
Mayo Clinic
Financial Performance
Stryker Revenue, 2005-2007 (US$ million)
Fig.25: Stryker Sales by Product Line, 2007*
Fig.26: Stryker’s Spinal Sales, 2003-2007 (US$ million)
Synthes
Synthes: Recent Spinal Product Launches
Alliances
Innovative Spinal Technologies
MTF (Musculoskeletal Transplant Foundation)
Financial Performance
Synthes Revenue, 2004-2007 (US$ million)
Zimmer
Zimmer: Recent Spinal Product Approvals
Spinal R&D Projects
Alliances
U&I Corporation
RTI Biologics
Financial Performance
Zimmer Revenue, 2004-2007 (US$ million)
Zimmer Spine Sales by Region, 2004-2007 (US$ million)

EMERGING PLAYERS

Allez Spine
Altiva (Exactech)
Amedica
Amedica: Recent Spinal Product Launches
Anulex Technologies
AOI Medical
Applied Spine Technologies
Archus Orthopedics
ArthroCare
Financial Performance
ArthroCare Revenue: 2005-2007 (US$ million)*
Arthro Kinetics
Financial Performance
Arthro Kinetics Revenue, 2005-2007 (EUR million)*
Atlas Spine
AxioMed Spine
Benvenue Medical
Biomerix
Cervitech
co.don
coLigne
CoreSpine Technologies
Corin
CryoLife
Custom Spine
Disc Dynamics
Disc Motion Technologies
Dynamic Spine
Eden Spine
Facet Solutions
Gentis
Gerraspine
GMReis
Impliant
Inion
Inion Revenue, 2006-2007 (EUR million)*
Innovative Spinal Technologies
Interventional Spine
Intrinsic Therapeutics
K2M
K2M: Recent Product Launches
Kensey Nash
Lanx
LDR Holding
LDR: Recent Product Launches
Life Spine
MEDICREA International
Nexgen Spine
Osteon
Paradigm Spine
Pioneer Surgical Technology
Pioneer: Recent Product Launches
Ranier Technology
Raymedica
Replication Medical
RSB Spine
Scient’x
Scient’x Revenue, 2004-2006 (US$ million)
SeaSpine
SIGNUS Medizintechnik
Sinitec
Smart Disc
Spinal Elements
Spinal Kinetics
SpinalMotion
Spinal Restoration
SpineMedica
Spineology
SpineOvations
SpineSmith
SpineVision
Spine Wave
Surgicraft
Theken Group (Integra LifeSciences)
Theken Spine
Theken Spine: Recent Spinal Product Approvals
Theken Disc
TranS1
Financial Performance
TranS1 Revenue, 2005-2007 (US$ million)*
ulrich medical
US Spine
Vertebration
Verterbron
VertiFlex
X-spine

APPENDICES

APPENDIX 1 - LIST OF ABBREVIATIONS
APPENDIX 2 - REPORT METHODOLOGY
Secondary Sources
Primary Sources
Market forecasts
Table of Contents
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