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Future Italian Tumor Marker Testing Market Outlook

February 2012 | 570 pages | ID: I41F5829B60EN
Venture Planning Group

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Highlights
  • Comprehensive 570-page analysis of the Italian tumor marker testing market.
  • Major issues pertaining to the Italian laboratory practice, as well as key economic, regulatory, demographic, social and technological trends with significant market impact during the next ten years.
  • Mortality statistics and scientific views on the etiology of major types of cancer, e.g., lung, colorectal, breast, prostatic, pancreatic, leukemia, lymphoma, gastrointestinal, bladder, liver, ovarian, testicular, oral, skin and others.
  • Ten-year test volume and sales forecasts for over 40 tumor marker performed in Italian hospitals and commercial laboratories.
  • Placements and installed base of automated and semi-automated analyzers used for tumor marker testing.
  • Current instrumentation technologies and feature comparison of leading analyzers.
  • Sales and market shares of leading suppliers.
  • Emerging diagnostic technologies and their potential market applications.
  • Product development opportunities.
  • Profiles of current and emerging suppliers, including their sales, market shares, product portfolios, marketing tactics, technological know-how, new products in R&D, collaborative arrangements and business strategies.
  • Business opportunities and strategic recommendations for suppliers.
Contains 570 pages and 83 tables
INTRODUCTION

WORLDWIDE MARKET AND TECHNOLOGY OVERVIEW

A. CANCER STATISTICS AND ETIOLOGY


1. Brest Cancer
2. Lung Cancer
3. Colon and Rectum Cancer
4. Prostate Cancer
5. Stomach Cancer
6. Leukemia
7. Lymphoma
8. Oral Cancer
9. Skin Cancer
10. Uterine Cancer
11. Ovarian Cancer
12. Bladder Cancer

B. MAJOR CURRENT AND EMERGING CANCER DIAGNOSTIC TESTS

1. Introduction
2. Tumor Marker Classification
3. ACTH
4. Alpha-Fetoprotein (AFP)
5. Beta-2 Microglobulin
6. CA 15-3/27.29
7. CA 19-9
8. CA-125
9. Calcitonin
10. Carcinoembrionic Antigen (CEA)
11. Estrogen and Progesterone Receptors
12. Ferritin
13. Gastrin
14. Human Chorionic Gonadotropin (HCG)
15. Insulin
16. NSE
17. Occult Blood
18. PAP Smear/HPV
19. Prostatic Acid Phosphatase (PAP)
20. Prostate-Specific Antigen (PSA)
21. Squamous Cell Carcinoma Antigen (SCC)
22. T and B Lymphocytes
23. TdT
24. Thyroglobulin
25. Tissue Polypeptide Antigen (TPA)
26. Biochemical Tumor Markers
    ADA
    B-Protein
    PNP
    5'-Nucleotidase
27. Oncogenes
    Abl/abl-bcr
    AIB1
    BCL-2
    BRCA1
    CD44
    C-fos
    C-myb
    C-myc
    CYP-17
    Erb-B
    HPC1
    N-myc
    P40
    P51
    P53
    PIK3CA
    PTI-1
    Ras
    Reg
    Sis
    Src
28. Polypeptide Growth Factors
  Basic Fibroblast Growth Factor
    Beta-TGF
    Cachectin (TNT)
    Calmodulin
    ECFR
    Nerve Growth Factor (NGF)
    Epidermal Growth Factor (EGF)
    Ornithine Decarboxylase
    Transferrin
    Transforming Growth Factor-Alpha
29. Ectopic Hormones
30. Colony Stimulating Factors
31. Lymphokines
    Alpha-Interferon
    B Cell Growth Factors
    B Cell Growth Factor (BCGF)
    Gamma-Interferon
    Interleukin-1 (IL-1)
    Macrophage Activating Factor
32. Immunohistochemical Stains
33. Emerging Tumor Markers
    N-Acetylglucosamine
    Actin
    Alpha-Actin
    Antineuronal Antibodies
    7B2
    B72.3
    Bax
    BCD-F9
    BLCA-4
    Blood Group Antigens A,B,H
    CA 50
    CA 72-4/TAG-72
    CA 195
    CA-242
    CA-549
    CAM 26
    CAR-3
    Cathepsin-D
    Chromogranin A and B
    Cluster 1 Antigen
    Cluster-5/5A Antigen
    CTA
    CU18
    DR-70
    DU-PAN-2
    Endometrial Bleeding Associated Factor
    Endostatin
    Epithelial Membrane Antigen
    Feulgen Hydrolysis
    Fibronectin
    FSH
    (1->3)-L-fucosyltransferase
    Gastrin-Releasing Peptide (GRP)
    GDCFP-15
    Glucagon
    Glycoamines
    H23
    Her-2
    Human Carcinoma Antigen
    HPA
    HSP27
    Intermediate Filaments
    Cytokeratins/CK18/Cyfra 21-1
    Desmin
    Gliofibrillary Acid Protein
    Neurofilaments
    Vimentin
    KA 93
    Kinases
    KP16D3
    LAI
    Leukocyte Common Antigen
    Lewis Antigens
    Lysophosphatidic Acid (LPA)
    Ma 695/Ma 552
    MABDF3
    MAG
    ME1
    Minactivin
    MN/CA9
    MSA
    Mucin Cancer Antigen (MCA)
    Multiple Tumor Suppressor 1
    Myosin
    NEA-130
    NMP22
    OA-519
    Opiod Peptides
    P-glycoprotein
    Pancreatic Oncofetal Antigen (POA)
    Placental Lactogen
    PR92
    Proliferative Index, Ki-67
    Px
    RB Inactivation/Deletion
    Ret
    SCCL 175
    Selectin
    Sialic Acid
    Sialyl SSEA-1/SLX
    SN10
    Somatostatin
    TA-90
    TABA
    Tachykinin
    TAG 12
    TPS
    Troponin
    Tubulin
    VCAM
    VEGF
    Villen

C. INSTRUMENTATION REVIEW AND MARKET NEEDS

1. Abbott AxSYM
2. Abbott Architect c4000
3. Abbott Architect i2000 Series
4. Abbott Architect ci8200 System
5. Beckman Coulter UniCel Series
6. Beckman Coulter Access
7. Binding Site ESP600
8. bioMerieux Mini Vidas
9. Carolina Chemistries BioLis 24i
10. DiaSorin Liaison
11. Horiba ABX Pentra 400
12. Inverness DS2
13. J&J Vitros ECi/ECiQ
14. J&J Vitros 3600
15. J&J Vitros 5600
16. Olympus AU5400
17. Olympus AU3000i
18. Olympus AU2700
19. Roche Modular Analytics
20. Roche Cobas Integra 400
21. Roche Cobas Integra 400 Plus
22. Roche Elecsys
23. Roche Cobas c311
24. Siemens ADVIA Centaur
25. Siemens Dimension
26. Siemens Dimension RxL Max
27. Siemens Dimension Vista 500
28. Siemens Immulite
29. Siemens Stratus
30. Tosoh AIA-Series
31. Vital Diagnostics ATAC 8000
32. Vital Diagnostics Envoy 500

D. CURRENT AND EMERGING TECHNOLOGIES

1. Monoclonal and Polyclonal Antibodies
2. Immunoassays
  a. Technological Principle
  b. Radioimmunoassay (RIA)
  c. Enzyme Immunoassays (EIA)
    Overview
    ELISA
    Immunofiltration
    Particle-Membrane Capture Immunoassay
    Enzyme Amplification
  d. Fluorescent Immunoassays
  e. Luminescence
    Chemiluminescence
    Bioluminescence
  f. Latex Agglutination
  g. Immunoprecipitation
  h. Affinity Chromatographu
  e. Liposome Flow-Injection Immunoassay
3. Molecular Diagnostics
  a. Technology Overview
  b. Amplification Methods
    PCR
    DAP-PCR
    Immuno-PCR
    QC-PCR
    CAR
    DNA
    HPA
    LCR
    NASBA
    QBR
    SDA
    3 SR, and others
4. Chromosome Analysis
  a. Chronic Myelogenous Leukemia (CML)
  b. Acute Myeloid Leukemia (AML)
  c. Acute Lymphoblastic Leukemia (ALL)
  d. Malignant Lymphomas Lymphoid Malignancies
  e. Chronic Lymphocytic Leukemia (CLL)
  f. Solid Cancers
  g. Chromosomal Translocation and Oncogenes
5. Artificial Intelligence
6. Flow Cytometry
7. Two Dimensional Gel Electrophoresis (2-DGE)
8. Biosensors
9. Competing/Complementing Technologies
  a. CT
  b. MRI
  c. NMR
  d. PET
  e. Photonics Spectroscopy

E. PERSONAL TESTING

  Italy
    A. Executive Summary
    B. Business Environment
    C. Market Structure
    D. Market Size, Growth and Major Suppliers
  Major Product Development Opportunities
    A. Reagent Kits and Test Systems/Panels
    B. Instrumentation
    C. Computers, Software and Automation
    D. Auxiliary Products
  Design Criteria for Decentralized Testing Products
  Alternative Market Penetration Strategies
    A. Internal Development
    B. Collaborative Arrangements
    C. University Contracts
    D. Distribution Strategies
1. Marketing Approaches
2. Product Complexity
3. Customer Preference
4. Established Suppliers
5. Emerging Suppliers
6. Major Types of Distributors
7. Market Segmentation Factor
  Potential Market Entry Barriers and Risks
  A. Market Maturity
    B. Cost Containment
    C. Competition
    D. Technological Edge and Limitations
    E. Patent Protection
    F. Regulatory Constraints
    G. Decentralized Testing Market Challenges
  Competitive Profiles
    Abbott
    AdnaGen
    Applied Gene Technologies
    Arca
    Beckman Coulter/Danaher
    Becton Dickinson
    Biomedical Diagnostics
    bioMerieux
    Bio-Rad
    Cepheid
    Correlogic Systems
    Dako
    Decode
    Diadexus
    Diagnocure
    Diasorin
    Eiken Chemical
    Enterix
    Enzo Biochem
    Epigenomics
    Exact Sciences
    Fujirebio
    Gen-Probe
    Guided Therapeutics
    Hologic
    Ipsogen
    Kreatech
    Kyowa Medex
    Life Technologies
    Mackay Life Sciences
    Myriad Genetics
    Nanogen Elitech
    OncoLab
    Otho-Clinical Diagnostics
    Panacea Pharmaceuticals
    Polartechnics
    Polymedco
    PreMD
    Qiagen
    Radient Pharmaceuticals
    Roche
    Scienion
    Sequenom
    Siemens Healthcare
    Takara Bio
    Targeted Diagnostics & Therapeutics
    Tosoh
    Veridex
    Wako Pure Chemicals
    Wallac/PE
    Zila

APPENDIXES

Appendix I: Major Universities and Research Centers Developing Cancer Diagnostic Technology and Applications
Appendix II: Assumed Currency Exchange Rates

LIST OF TABLES

Tumor Marker Classification
Major Companies Developing or Marketing ACTH Tests
Major Companies Developing or Marketing AFP Tests
Major Companies Developing or Marketing Beta-2 Microglobulin Tests
Major Companies Developing or Marketing CA 15-3/27.29 Tests
Major Companies Developing or Marketing CA 19-9 Tests
Major Companies Developing or Marketing CA 125 Tests
Major Companies Developing or Marketing Calcitonin Tests
Major Companies Developing or Marketing CEA Tests
Major Companies Developing or Marketing Estrogen Receptor Tests
Major Companies Developing or Marketing Progesterone Receptor Tests
Major Companies Developing or Marketing Ferritin Tests
Major Companies Developing or Marketing Gastrin Tests
Major Companies Developing or Marketing HCG Tests
Major Companies Developing or Marketing Insulin Tests
Major Companies Developing or Marketing NSE Tests
Major Companies Developing or Marketing Occult Blood Tests
Major Companies Developing or Marketing PAP Smear/HPV Tests
Major Companies Developing or Marketing PAP Tests
Major Companies Developing or Marketing PSA Tests
Major Companies Developing or Marketing Lymphocyte Subclassification Tests
Biochemical Markers Potential Applications In Cancer Diagnosis
Oncogenes Potential Applications In Cancer Diagnosis
Major Companies Developing or Marketing Oncogene Tests
Growth Factors Potential Applications In Cancer Diagnosis
Colony Stimulating Factors Potential Applications in Cancer Diagnosis
Lymphokines Potential Applications In Cancer Diagnosis
Immunohistochemical Stains Potential Applications in Cancer Diagnosis
Executive Summary Table: Italy, Total Tumor Marker Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Estimated Cancer Death Rates Per 100,000 Population
Italy, Laboratories Performing Tumor Marker Tests by Market Segment
Italy, Hospital Laboratories Performing Tumor Marker Tests by Bed Size
Italy, Commercial/Private Laboratories Performing Tumor Markers by Annual Test Volume
Italy, Total Tumor Marker Test Volume Forecast by Market Segment
Italy, All Market Segments Major Cancer Diagnostic Test Volume Forecast
Italy, Hospital Laboratories Major Tumor Marker Test Volume Forecast
Italy, Commercial/Private Laboratories Major Tumor Marker Test Volume Forecast
Italy, Total Tumor Marker Test Market Forecast by Market Segment
Italy, All Market Segments Major Tumor Marker Sales Forecast by Test
Italy, Hospital Laboratories Major Tumor Marker Forecast by Test
Italy, Commercial/Private Laboratories Major Tumor Marker Sales Forecast by Test
Italy, ACTH Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, AFP Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Beta-2 Microglobulin Test Volume And Diagnostics Sales Forecast by Market Segment
Italy, CA 15-3/27.29 Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, CA-19-9 Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, CA 125 Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Calcitonin Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, CEA Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Chromogranin Test Volume And Diagnostics Sales Forecast by Market Segment
Italy, Colon Specific Antigen Test Volume And Diagnostics Sales Forecast by Market Segment
Italy, Cytokeratins Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Estrogen Receptor Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Ferritin Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Gastrin Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, HCG Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Insulin Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Lymphocyte Subtyping Test Volume And Diagnostics Sales Forecast by Market Segment
Italy, NSE Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Occult Blood Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Oncogenes Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Pancreatic Oncofetal Antigen Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, PAP Smear Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Parathyroid Hormone Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Progesterone Receptor Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, PAP Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, PSA Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, S-100 Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Serotonin Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Sialic Acid Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Squamous Cell Carcinoma Antigen Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, TDT Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Thymidine Kinase Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Thyroglobulin Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, TPA Test Volume and Diagnostics Sales Forecast by Market Segment
Italy, Total Tumor Markers Sales by Major Suppliers
Italy, AFP Testing Market Diagnostics Sales by Major Supplier
Italy, CEA Testing Market Diagnostics Sales by Major Supplier
Italy, PSA Testing Market Diagnostics Sales by Major Supplier


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