Future Horizons and Growth Strategies in the Italian Nucleic Acid Testing Market 2015: Supplier Shares and Country Forecasts

June 2015 | 1117 pages | ID: 2B74E54F08AEN
Venture Planning Group

Abstracts

Highlights

• Comprehensive 1,117-page market segmentation analysis of the Italian NAT market.
• Major issues pertaining to the Italian NAT laboratory practice, as well as key economic, regulatory, demographic, social and technological trends with significant market impact during the next five years.
• An extensive review of DNA probe and biochip technologies, test formats, detection methodologies, trends in testing automation and amplification methods.
• Five-year test volume and reagent sales forecasts for the following categories:

• Infectious Diseases
• Cancer
• Forensic Testing
• Genetic Diseases
• Paternity Testing/HLA Typing

• Review of testing methodologies and instrumentation technologies.
• Feature comparison of automated and semiautomated analyzers.
• Sales and market shares of leading suppliers.
• Over 60 specific opportunities for NAT instruments, test systems, IT and auxiliary products.
• Profiles of major suppliers, and emerging market entrants, including their sales, product portfolios, marketing tactics, technological know-how, new products in R&D, collaborative arrangements and business strategies.
• Alternative market penetration strategies.
• Potential market entry barriers and risks.
• Business planning issues and concerns.

Contains 1,117 pages and 55 tables

Contents

INTRODUCTION

WORLDWIDE MARKET AND TECHNOLOGY OVERVIEW

A. DNA Sequencing
  1. Introduction
  2. Sequencing Methods
  3. Autoradiography
  4. The Human Genome Project
  5. Sequencing Automation
  6. Image Scanners
  7. Fluorescent Detection
  8. Gene Profiling
  9. Gene Expression
  10. Polymorphism Screening
  11. Protein Interaction Networks
B. DNA And RNA Probe Technology
  1. Basic Principles
  2. Probe Preparation
  3. The DNA Probe Test
    a. Sample Preparation
    b. Hybridization
    c. Separation
    d. Detection/Measurement
  4. Test Formats
    a. Filter Hybridization
    b. Southern Blot
    c. Northern Blot
    d. In Situ Hybridization
    e. Others
  5. Labeling Techniques
  6. Amplification Methods
    Polymerase Chain Reaction
      Temperature Cyclers
      PCR Variations
        Immuno-PCR
        QC-PCR
        DAP-PCR
    Strand Displacement Activation
    TMA
    Ligase Chain Reaction
    Branched DNA
      Hybridization Protection Assay
    Nucleic-Acid Sequence-Based Amplification
    Self-Sustained Sequence Replicase
    Others
      Ampliprobe
      CAR
      CAS
      CPT
      Dendritic Polymer Technology
      ISO-CR
      LAT
      Probe Networks
      RAMP
      Repair Chain Reaction
      Rolling Circles
      Sequence Independent Gene Amplification
      Sequence Initiation Reaction
      SISPA
      Solid Phase Amplification
C. Detection Technologies
  1. Radioactive Methods
    a. Overview
    b. Major Isotopes
      P-32
      S-35
      H-3
      I-125
  2. Non-Isotopic Methods
    a. Enzymatic Labels
    b. Chemical Labeling
      Indirect Chemical Labeling
      Direct Chemical Labeling
    c. Fluorescence
    d. Chemiluminescence
    e. Electrical Conductivity
D. Instrumentation Review
  1. Abbott LCx
  2. Beckman Coulter/Biomek FK
  3. Becton Dickinson SDA
  4. Bio-Rad GeneScope
  5. Gen-Probe Tigris
  6. Roche Cobas Amplicor
  7. Tecan LS Series
E. Biochips: Genosensors, Microarrays, and Labs-on-the-Chip
  Liquid Transportation and Mixing
  Separation
  Reaction
  Detection
F. Pharmacogenomics
G. Major Applications
  1. Microbiology/Infectious Diseases
    a. Overview
    b. Major Infectious Diseases
        AIDS
      Structure and Composition
      Classification
      AIDS Origins
      Animal Lentivirus Systems
      Virus Receptors
      HIV Infections in Humans
        Pathogenesis and Pathology
      CD4T Lymphocytes and Memory Cells
      Monocytes and Macrophages
      Lymphoid Organs
      Neural Cells
      Viral Coinfections
        Clinical Findings
      Plasma Viral Load
      Pediatric AIDS
        Neurologic Disease
        Opportunistic Infections
        Cancer
      Immunity
        Virus Isolation
        Serology
        Viral Nucleic Acid/Antigen Detection
      Epidemiology
        Worldwide Spread of AIDS
        United States
        Routes of Transmission
      DNA Probes
      Overview
        Quantitative PCR
        In Situ PCR
        Needed Improvements
      Viral Load/Drug Resistance Testing
      Genotype and Phenotype Testing
      Blood Banking Considerations
        Adenovirus
      Background
      Diagnostic Tests
      Vaccines and Drugs
      Adeno-Associated Viruses (AAV)
        Anthrax/Bacillus Anthracis
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Babesiosis
      Background
        BEA and Other Bartonella Diseases
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Chagas Disease
      Background
        Campylobacter
      Background
      Diagnostic Tests
        Culture Identification
      Vaccines and Drugs
        Chlamydia
      Background
        Chlamydia psittaci
        Chlmaydia pneumoniae
        Chlamydia trachomatis
      Diagnostic Tests
      Vaccines and Drugs
        Creutzfeldt-Jakob’s Disease
      Background
      Blood Transmission
      Diagnostic Tests
      Major Commercial and Academic Players
        Bayer
        Disease Sciences/Bio Tec Global
        Imperial College School of Medicine
Ortho-Clinical Diagnostics
        Pall
        ProMetic Life Sciences
Proteome Sciences/Idexx
        Q-One Biotech
        Serono
        U.S. Agricultural Research Service
      Drugs
      Vaccines
        Cytomegalovirus
      Background
        Chorioretinitis
        Gastrointestinal
        Central Nervous System Disease
      Diagnostic Tests
      Vaccines and Drugs
        Ebola Virus
      Background
  Epidemiology
  Clinical Syndromes
      Diagnostic Tests
      Vaccines and Drugs
        EchoVirus
      Background
        Acute Aseptic Meningitisis
        Encephalitis
        Exanthems
        Respiratory Disease
        Myopericarditis
        Neonatal Infections
      Diagnostic Tests
      Vaccines and Drugs
        Encephalitis
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Enteroviruses
      Background
      Diagnostic Tests
        Viral Isolation and Identification
        Antibody Tests
      Vaccines and Drugs
        Epstein-Barr Virus
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Gonorrhea
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Hepatitis
      Hepatitis A
      Hepatitis B
        Structure and Composition
        Replication
      Hepatitis C
      Hepatitis D (Delta)
      Hepatitis E
      Hepatitis G
      Hepatitis Infections Pathology
      Clinical Findings
      Laboratory Tests
        Hepatitis A
        Hepatitis B
        Hepatitis C
        Hepatitis D
        Hepatitis E
      Virus-Host Immune Reactions
      Epidemiology
        Hepatitis A
        Hepatitis B
        Hepatitis C
        Hepatitis D (Delta)
      Vaccines and Drugs
        Herpes Simplex Virus
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Legionella
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Lyme Disease
      Background
        Clinical Description
        Clinical Case Definition
        Laboratory Criteria for Diagnosis
        Case Classification
      Diagnostic Tests
      Vaccines and Drugs
        Malaria
        Mycoplasma
      Background
        Ureaplasma Urealyticum & Mycoplasma Hominis
      Diagnostic Tests
      Vaccines and Drugs
        Papillomaviruses/HPV
      Background
        HPV in Cancer
        Cervical Neoplasm
      Diagnostic Tests
      Vaccines and Drugs
        Prevention
        Parvovirus B19
      Background
  Microbiology
  Epidemiology
  Clinical Syndromes
        Erythema Infectiosum (Slapped Cheek)
        Adult Polyarthropathy
        Transient Aplastic Crisis
        Transient Pancytopenia
        Red Cell Aplasia in Immunocompromised
        Perinatal Infections
      Diagnostic Test
      Vaccines and Drugs
        Pneumonia
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Polyomaviruses
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Salmonellosis
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Shigellosis
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Streptococci
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Group A Streptococci
        Group B Streptococci
        Toxoplasmosis
      Background
      Diagnostic Tests
      Vaccines and Drugs
        Tuberculosis
      Background
      Diagnostic Tests
        Microscopic Characteristics
        Cultural Characteristics
        Skin Tests
        MDRTB
      Vaccines and Drugs
        West Nile Virus
      Background
  Clinical Syndromes
      Diagnostic Tests
      Vaccines and Drugs
        Yersinia
      Background
      Diagnostic Tests
      Vaccines and Drugs
    c. Antibiotic Susceptibility
  2. Cancer Testing
    a. Overview
    b. Major Cancer Types
        Prostate
        Lung
        Colon and Rectum
        Breast
        Skin
        Uterine
        Leukemia
        Oral
    c. Oncogenes
      Abl/abl-bcr
      AIB1
      BCL-2
      BRCA1
      CD44
      C-fos
      C-myb
      C-myc
      CYP17
      Erb-B
      HPC1
      N-myc
      P40
      P51
      P53
      PIK3CA
      PTI-1
      Ras
      Reg
      Sis
      Src
  3. Genetic Diseases
    a. Overview
    b. Nucleic Acid Amplification
    c. Chromosome Imaging
    d. Genomics Technologies
    e. Proteomics Technologies
    f. Current Pharmacogenomic Tests
    g. Future Pharmacogenomic Testing
    h. Major Diseases
        Achondroplasia
        Autosomal Dominant Polycystic Kidney Disease
        Cancer
        Cosmetogenomics
        Cystic Fibrosis
        Down's Syndrome
        Duchenne and Becker Muscular Dystrophy
        Factor V (Leiden)
        Factor IX Deficiency
        Fragile X Syndrome
        Heart Disease
        Hemochomatosis
        Hemophilia
        Huntington's Disease
        Maternal-Fetal Incompatibility
        Multiple Endocrine Neoplasia
        Phenylketonuria (PKU)
        Polycystic Kidney Disease (PKD)
        Prenatal Screening
        Retinitis Pigmentosa
        Retinoblastoma
        Sickle Cell Anemia
        Spinal Muscular Atrophy
        Vitamin B12 Metabolism
    i. Social Issues and Concerns
  4. Forensic Testing
    a. Overview
    b. Multilocus and Single Locus Probes
        Multilocus Probes
        Single Locus Probes
        PCR and RFLP
    c. The FBI
    d. DNA Profile Data Banks
        U.S.A.
        U.K.
    e. Judicial Implementation
    f. Major Crime Categories
    g. Factors Contributing to the DNA Probe Market Expansion
        Technology Availability
        Use of Hair as Evidence
    h. Wildlife Forensics
  5. Paternity Testing/HLA Typing
  6. Other Applications
    a. Disease Susceptibility Testing
    b. Cardiovascular Diseases
    c. Diabetes
    d. Alzheimer's Disease
    e. Periodontal Disease
    f. Plasma Purification
    g. Organ Transplantation
    h. Water Contamination
    i. Other
H. Competing/complementing Technologies
1. Monoclonal Antibodies/Immunoassays
  2. RNA Probes
  3. Two-Dimensional Electrophoresis
  4. Flow Cytometry

I. WORLDWIDE MARKET OVERVIEW

  1. Business Environment
  2. Market Structure
  3. Market Size and Growth

ITALY

A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers’ Sales And Market Shares

MAJOR PRODUCT DEVELOPMENT OPPORTUNITIES

A. Instrumentation
B. Reagent Kits and Test Systems/panels
C. Computers, Software and Automation
D. Auxiliary Products

DESIGN CRITERIA FOR DECENTRALIZED TESTING PRODUCTS

ALTERNATIVE MARKET PENETRATION STRATEGIES

A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies For Decentralized Testing Markets
  1. Marketing Approaches
  2. Product Complexity
  3. Customer Preference
  4. Established Suppliers
  5. Emerging Suppliers
  6. Major Types Of Distributors
  7. Market Segmentation

POTENTIAL MARKET ENTRY BARRIERS AND RISKS

A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge And Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges

COMPETITIVE PROFILES

Abbott
Affymetrix
Agilent
Applied Gene Technologies
Arca
Beckman Coulter/Danaher
Becton Dickinson
Biokit
BioMerieux
Bio-Rad
Biotest
Caliper
Cepheid
Decode
Diadexus
Eiken
Enzo
Exact Sciences
Fujirebio
Gen-Probe
Hologic
Illumina
Innogenetics/Solvay
Kreatech
Li-Cor Biosciences
Life Technologies
Monogram Biosciences
Myriad Genetics
Nanogen/Elitech
Novartis
Orchid CellMark
Ortho-Clinical Diagnostics
Proteome Sciences
Qiagen
Roche
Scienion
Sequenom
Shimadzu
Siemens
Sierra Molecular
Takara Bio
Tecan Group

APPENDIXES

Appendix I: Major Universities and Research Centers Developing NAT Technology
Appendix II: Glossary of Terms
Appendix III: Currency Exchange Rates

List Of Tables

LIST OF TABLES

Major Companies Developing or Marketing AIDS NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Adenovirus NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Campylobacter NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Chlamydia NAT And Other Direct Identification Tests
Major Companies Developing or Marketing CMV Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing EBV Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Gonorrhea NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Hepatitis NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Herpes NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Legionella NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Lyme Disease NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Mycoplasma NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Papilloma Virus NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Pneumonia NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Salmonella NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Shigella NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Streptococci NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Toxoplasmosis NAT And Other Direct Identification Tests
Major Companies Developing or Marketing Tuberculosis NAT And Other Direct Identification Tests
Oncogenes Potential Application in Cancer Diagnosis
Major Companies Developing or Marketing Cancer NAT Tests
Major Companies Developing or Marketing NAT Assays For Genetic Diseases
Summary Table Italy, NAT Test Volume And Sales Forecast by Major Application
Italy, Laboratories Performing DNA Sequencing by Market Segment
Italy, NAT Market Potential Laboratory Universe by Market Segment
Italy, NAT Test Volume Forecast By Major Application
Italy, Major Infectious NAT Test Volume Forecast
Italy, Infectious Disease Screening NAT Volume Forecast
Italy, NAT Market Forecast By Major Application
Italy, Infectious Disease Screening NAT Reagent Market Forecast by Test
Italy, NAT Market By Major Supplier
Italy, HIV/Hepatitis NAT Market By Major Supplier